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Updated: Jul 2, 2026
07:59
Functional Characterization of Endogenously Expressed Human RYR1 Variants
Published on: June 9, 2021
Reye's and Reye's-like syndromes
Agostino Pugliese1, Tiziana Beltramo, Donato Torre
1Department of Medical and Surgical Sciences, Teaching of Clinical Virology in Post Doctoral Schools of Medicine, University of Turin, "Amedeo di Savoia" Hospital, Turin, Italy. agostino.pugliese@unito.it
Cell Biochemistry and Function
|August 20, 2008
Summary
Reye
Area of Science:
- Pediatric Neurology
- Biochemistry
- Toxicology
Background:
- Classic Reye's syndrome cases have decreased due to reduced salicylate use in children.
- Reye's-like syndromes remain a concern, presenting with diverse etiologies.
- Metabolic disorders, particularly in fatty acid and amino acid metabolism, are key predisposing factors.
Purpose of the Study:
- To review Reye's syndrome and Reye's-like syndromes.
- To examine the role of metabolic disorders and exogenous factors in these conditions.
- To discuss salicylate-induced Reye's syndrome mechanisms and diagnostic differentiation.
Main Methods:
- Literature review of Reye's syndrome and Reye's-like syndromes.
- Analysis of etiological and predisposing factors, including metabolic disorders.
- Examination of biochemical mechanisms and diagnostic criteria.
Main Results:
- Salicylates are a primary inducer of Reye's syndrome in children with viral infections.
- Latent metabolic disorders can be triggered by viral infections, toxins, or drugs, leading to Reye's-like syndromes.
- Biochemical mechanisms of salicylate-induced Reye's syndrome are detailed.
Conclusions:
- While classic Reye's syndrome is less common, Reye's-like syndromes necessitate continued investigation.
- Understanding metabolic predispositions is crucial for identifying individuals at risk.
- Accurate diagnostic differentiation and therapeutic strategies are essential for managing these complex conditions.
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