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Behavioral tolerance to flurazepam.

C E Lau1, S Dolan, M Tang

  • 1Department of Psychology--Busch, Rutgers University, New Brunswick, NJ 08903.

Pharmacology, Biochemistry, and Behavior
|April 1, 1991
PubMed
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Behavioral tolerance to flurazepam developed in rats. Post-session injections led to tolerance in lever pressing but not time to reward, indicating timing impacts tolerance development.

Area of Science:

  • Pharmacology
  • Behavioral Neuroscience

Background:

  • Flurazepam is a benzodiazepine with sedative and anxiolytic properties.
  • Understanding drug tolerance is crucial for optimizing therapeutic use and managing side effects.

Purpose of the Study:

  • To investigate the development of behavioral tolerance to flurazepam in rats.
  • To examine how the timing of flurazepam administration (pre-session vs. post-session) influences tolerance development.

Main Methods:

  • Rats were trained on a fixed-interval schedule to earn food pellets.
  • Flurazepam (16 mg/kg) was administered either before or after training sessions for several weeks.
  • Behavioral responses, including lever presses and time to earn rewards, were monitored.

Main Results:

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  • Rats receiving weekly pre-session flurazepam injections developed behavioral tolerance by the second injection.
  • Rats receiving post-session injections showed subsequent tolerance to pre-session flurazepam for lever pressing, but not for time to earn rewards.
  • No dispositional tolerance to flurazepam's serum elimination rate was observed.

Conclusions:

  • The timing of drug administration significantly impacts the development of behavioral tolerance to flurazepam.
  • Tolerance to flurazepam's effects on lever pressing can develop even with post-session administration, suggesting distinct mechanisms.
  • Further research is needed to elucidate the neurobiological underpinnings of timing-dependent tolerance.