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Related Experiment Videos

A silicone pellet for continuous cocaine: comparison with continuous amphetamine.

J Lipton1, S Zeigler, J Wilkins

  • 1Department of Psychology, University of California, Los Angeles, CA 90024.

Pharmacology, Biochemistry, and Behavior
|April 1, 1991
PubMed
Summary

A new silicone pellet allows for 5-day continuous cocaine administration in rats, revealing distinct behavioral stages including hyperactivity, stereotypies, and hallucinogen-like effects.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Continuous drug administration models are crucial for understanding long-term substance effects.
  • Cocaine's acute and chronic effects on behavior are complex and require precise delivery methods.

Purpose of the Study:

  • To develop and validate an inexpensive silicone pellet for sustained cocaine delivery.
  • To characterize the behavioral effects of continuous cocaine administration in rats.

Main Methods:

  • Development of a silicone pellet for controlled, continuous cocaine release over 5 days.
  • Implantation of pellets in rats and observation of behavioral changes.
  • Comparison of cocaine's effects with those of continuous d-amphetamine administration.

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Main Results:

  • The silicone pellet enabled up to 5 days of cocaine administration with minimal skin irritation.
  • Rats exhibited sequential behavioral stages: initial hyperactivity, followed by motor stereotypies.
  • Hallucinogen-like behaviors (limb flicks, startle responses, grasping) emerged at 3-4 days.
  • Continuous cocaine induced fewer motor stereotypies but more "late-stage" behaviors than d-amphetamine.

Conclusions:

  • The silicone pellet is an effective tool for studying long-term cocaine exposure and its behavioral consequences.
  • Continuous cocaine administration produces a unique behavioral profile distinct from other stimulants like d-amphetamine.
  • This model facilitates research into the neurobiological underpinnings of chronic stimulant use and hallucinogen-like effects.