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Published on: April 29, 2014
Expression profile of metastasis-related genes in invasive oral cancers
Y Y Chiang1, M H Tsai, T Y Lin
1Department of Dental Laboratory Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan. YYChiang668@gmail.com
Abstract:
We used suppression subtractive hybridization (SSH) and oligonucleotide microarray to differentiate expression profiles of metastasis-related genes and to evaluate their clinical significance in patients with invasive oral cancer (OCa). Overexpression of the specific genes was confirmed by reverse transcription-PCR (RT-PCR). Cells expressing the gene were identified by immunohistochemistry in pathology specimens. Clinical correlation and significance were analyzed statistically. Using these methods, we detected increased expressions of MMP-1, -3, -7, -9, -10 and interleukin (IL)-8 in invasive OCa. Moreover, our data showed that overexpressions of MMP-1, -3, -7, -10 and IL-8 were associated with reduced survival.
