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Methylthioadenosine phosphorylase expression in cutaneous squamous cell carcinoma

Hasen M Alhebshi1, Ishita Pant, Gurjeet Kaur

  • 1Institute of Medicine, University of Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei Darussalam.

Asian Pacific Journal of Cancer Prevention : APJCP
|August 21, 2008
PubMed

Insights

Methylthioadenosine phosphorylase (MTAP) protein expression was investigated in cutaneous squamous cell carcinoma (SCC). MTAP protein levels did not significantly differ between SCC and normal skin, suggesting it does not play a role in SCC development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • The methylthioadenosine phosphorylase (MTAP) gene, a tumor suppressor, is located near frequently deleted p15 and p16 genes in tumor cells.
  • The role of MTAP protein expression in cutaneous squamous cell carcinoma (SCC) genesis is unknown.
  • Previous studies indicated allelic imbalance/loss of heterozygosity (AI/LOH) and reduced p15/p16 protein expression in cutaneous SCCs.

Purpose of the Study:

  • To determine the role of MTAP protein expression in the genesis of cutaneous SCC.
  • To investigate MTAP protein expression in comparison to normal human skin.

Main Methods:

  • Immunohistochemical analysis of MTAP protein expression.
  • Analysis of 109 cutaneous SCC and 20 normal human skin tissue samples using microarrays.

Main Results:

  • MTAP protein expression levels were not significantly different between cutaneous SCC samples and normal human skin.
  • No significant association was found between MTAP protein expression and the development of cutaneous SCC.

Conclusions:

  • MTAP protein expression does not appear to contribute to the genesis of cutaneous squamous cell carcinoma.
  • Further research may be needed to fully elucidate the role of MTAP in skin carcinogenesis.

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