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New vistas on 5-HT receptors and migraine
1Department of Neurology, Stanford University Medical Center, CA.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|January 1, 1991
Abstract:
1. A number of serotonergic agents have been shown to be effective in the treatment of migraine. At the present time, migraine drug interactions have been analyzed most extensively at 5-hydroxytryptamine1D (5-HT1D), 5-HT2 and 5-HT3 receptor subtypes. 2. This review will summarize the current status of 5-HT receptor subtypes as they relate to anti-migraine agents. 3. The available data suggest that drug interactions with specific 5-HT receptor subtypes may be the basis for their efficacy in both the acute and prophylactic treatment of migraine.