Related Experiment Video
Updated: Jul 2, 2026
Spontaneous and Evoked Measures of Pain in Murine Models of Monoarticular Knee Pain
Published on: February 22, 2019
Incidence of erythromelalgia: a population-based study in Olmsted County, Minnesota
1Mayo Medical School, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Objective:
To estimate the population-based incidence of erythromelalgia. Background Only one report describing the incidence of erythromelalgia has been published previously.
Study Design:
A population-based analysis of data from the Rochester Epidemiology Project.
Setting:
Tertiary care medical centre in Olmsted County, Minnesota (a rural county in the south-eastern portion of the state).
Patients:
Thirty-three residents of Olmsted County with a diagnosis of erythromelalgia during the study period.
Methods:
Age- and sex-specific incidence rates of erythromelalgia were determined.
Intervention:
None.
Main Outcome:
Population-based incidence rate.
Results:
The overall age- and sex-adjusted incidence rate (95% confidence interval, 95% CI) was 1.3 (0.8-1.7) per 100,000 people per year. The incidence of primary and secondary erythromelalgia was 1.1 (0.7-1.5) and 0.2 (0.02-0.4) per 100,000 people per year, respectively. The age-adjusted incidence rates (95% CI) were 2.0 (1.2-2.7) per 100,000 women and 0.6 (0.1-1.1) per 100,000 men. The study was limited by the small sample size and potential variability in recognition of erythromelalgia.
Conclusion:
The population-based incidence of erythromelalgia has increased with each decade in Olmsted County over the past three decades; overall incidence was 1.3 per 100,000 people per year, approximately 5 times higher than previously reported.
