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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

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Related Experiment Video

Updated: Jul 2, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma.

Ulaganathan Mabalirajan1, Amit Kumar Dinda, Sarvesh Kumar

  • 1Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi, India.

Journal of Immunology (Baltimore, Md. : 1950)
|August 21, 2008
PubMed
Summary
This summary is machine-generated.

Asthma pathogenesis involves Th2-dominant responses and airway oxidative stress. This study reveals mitochondrial dysfunction in allergic asthma, which can be reversed by targeting Interleukin-4 (IL-4) pathways, suggesting new therapeutic strategies.

Related Experiment Videos

Last Updated: Jul 2, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Immunology
  • Cell Biology
  • Pathophysiology

Background:

  • Asthma pathogenesis is linked to Th1/Th2 immune imbalance and airway oxidative stress.
  • Mitochondria's role in asthma-related oxidative stress and dysfunction is not well understood.

Purpose of the Study:

  • To investigate mitochondrial dysfunction in experimental allergic asthma.
  • To explore the potential of targeting IL-4 pathways for reversing asthma-associated mitochondrial changes.

Main Methods:

  • Ovalbumin (OVA)-induced allergic asthma model in BALB/c mice.
  • Assessed mitochondrial function (cytochrome c oxidase activity, ATP levels) and structure in lung tissues.
  • Evaluated the effects of anti-IL-4 monoclonal antibody (mAb) and anti-IFN-gamma mAb administration.

Main Results:

  • Allergic asthma induced mitochondrial dysfunction, including reduced cytochrome c oxidase activity and ATP levels, and altered mitochondrial ultrastructure.
  • These dysfunctions were reversed by anti-IL-4 mAb treatment.
  • Anti-IFN-gamma mAb did not reverse mitochondrial changes, and airway hyperresponsiveness worsened.

Conclusions:

  • Mitochondrial structural changes and dysfunction are associated with allergic asthma.
  • Targeting IL-4 pathways shows promise for mitigating asthma-related mitochondrial pathology.
  • Findings suggest mitochondria as a potential therapeutic target for asthma treatment.