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Updated: Jul 2, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Stress, health and ageing: a focus on postmenopausal women
Oliver T Wolf1, Brigitte M Kudielka
1Department of Cognitive Psychology, Ruhr-University Bochum, Universitätsstrasse 150, D-44780 Bochum, Germany. oliver.t.wolf@rub.de
Abstract:
Stress influences health and disease and this might be of special relevance for ageing. The present review starts with the description of age-associated changes of the hypothalamic-pituitary-adrenal axis. In this context, the possible modulatory role of estradiol is discussed. Later, the influence of rising stress hormone levels for the ageing brain is illustrated and a few intervention strategies are outlined. At the end, the concept of allostatic load (AL) is described, which aims at a broader assessment of the impact of stress on the individual. The strengths and also the current limitations of the AL concept are highlighted.
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