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Related Experiment Video

Updated: Jul 2, 2026

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Published on: September 1, 2016

Bupropion-induced angioedema.

Amy E Tackett¹, Kelly M Smith

¹University of Kentucky College of Pharmacy, Lexington, USA. aetack2@uky.edu

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|August 21, 2008

Summary

This summary is machine-generated.

Bupropion, used for smoking cessation, can cause angioedema, a rare but serious adverse effect. Prompt drug discontinuation is crucial to resolve symptoms and prevent complications.

Related Experiment Videos

Last Updated: Jul 2, 2026

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Published on: September 1, 2016

Area of Science:

Pharmacology
Adverse Drug Reactions

Background:

Bupropion is a commonly prescribed medication for smoking cessation.
Angioedema is a rare but potentially severe adverse effect associated with bupropion use.

Observation:

A 33-year-old male smoker developed angioedema 18 days after starting bupropion.
Symptoms included rash, pruritus, and swelling of extremities, lips, and tongue, requiring emergency care.
Re-challenge with bupropion led to symptom recurrence, confirming the drug as the causative agent.

Findings:

Bupropion was identified as the definitive cause of angioedema based on symptom recurrence after re-exposure.
The patient's angioedema resolved after discontinuing bupropion and receiving supportive treatment.
This case highlights the importance of recognizing bupropion-induced angioedema.

Implications:

Failure to identify and remove the causative agent (bupropion) can lead to prolonged symptoms and increased healthcare costs.
Clinicians should maintain a high index of suspicion for angioedema in patients taking bupropion.
Early recognition and discontinuation of bupropion are essential for managing this adverse reaction.