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Angiotensin II increases MAO activity in rat central nervous system
1Departamento de Ciencias, Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Revista Espanola De Fisiologia
|March 1, 1991
Abstract:
The effects of angiotensin II (ANG II) and bilateral nephrectomy on monoamine oxidase (MAO) activity were studied in rat hypothalamus and medulla oblongata. ANG II increased MAO activity in both central nervous system (CNS) regions. The fall of circulating ANG II caused by 48 h bilateral nephrectomy decreased the activity of the enzyme in the mentioned areas. The results showed that ANG II stimulates catecholamine metabolism in the CNS.