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Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
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Hemostasis abnormalities in liver cirrhosis: myth or reality?

Armando Tripodi1

  • 1Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milano, Italy. armando.tripodi@unimi.it

Polskie Archiwum Medycyny Wewnetrznej
|August 22, 2008
PubMed

Chronic liver disease is characterized by a global hemostatic defect that includes platelet-vessel wall interaction (primary hemostasis), fibrinolysis and coagulation causing abnormalities of the relevant laboratory tests. The causal relationship between abnormal tests and bleeding has been widely accepted, despite the fact that abnormal tests are poorly associated with bleeding. Recent evidence from the literature disputes the above paradigm and open new directions for laboratory and clinical research in this field.

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