Prochiral and chiral resolution in 2H NMR spectra: solutes in stretched and compressed gelatin gels
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Updated: Feb 14, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Christoph Naumann1, Philip W Kuchel
1School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia.
Abstract:
We demonstrate prochiral and chiral spectral resolution using residual (2)H NMR quadrupolar splittings over a wide range of anisotropic conditions in liquid samples. We use a reversible gel-stretching/compressing device in a conventional high-field NMR spectrometer. We show the stability of gelatin gels as well as their unique ability to switch between multiple stretched and compressed states, thus also changing the sign of residual dipolar couplings in (1)H and (13)C NMR. This flexibility will be important for resolving spectra of mixtures of other chiral compounds and for structure determination of selected peptides.
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