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Updated: Jul 2, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Preventing ventilator-associated pneumonia in the United States: a multicenter mixed-methods study
Sarah L Krein1, Christine P Kowalski, Laura Damschroder
1Department of Veterans Affairs Ann Arbor Health Services Research and Development Center of Excellence, University of Michigan Medical School, Ann Arbor, Michigan 48113, USA. skrein@umich.edu
Hospitals commonly use semirecumbent positioning to prevent ventilator-associated pneumonia (VAP). Subglottic secretion drainage is used less often due to debates about its supporting evidence and implementation challenges.
Area of Science:
- Infection Control
- Respiratory Medicine
- Healthcare Quality Improvement
Background:
- Ventilator-associated pneumonia (VAP) is a significant healthcare-associated infection.
- Effective prevention strategies are crucial for improving patient outcomes and reducing healthcare costs.
Purpose of the Study:
- To identify current hospital practices for VAP prevention.
- To qualitatively explore the reasons behind the adoption or non-adoption of specific VAP prevention methods.
Main Methods:
- A mixed-methods, sequential explanatory study design was employed.
- Surveys were distributed to infection control professionals at 719 US hospitals.
- Qualitative in-depth investigations, including interviews and site visits, were conducted at 14 selected hospitals.
Main Results:
- Semirecumbent positioning was utilized by 83% of hospitals, while subglottic secretion drainage was used by only 21%.
- Collaborative initiatives were associated with semirecumbent positioning use, but not subglottic secretion drainage.
- Qualitative findings indicated strong influence of collaboratives and nurses on semirecumbent positioning, contrasting with limited adoption and evidence debate surrounding subglottic secretion drainage.
Conclusions:
- Semirecumbent positioning is a widely adopted VAP prevention practice, unlike subglottic secretion drainage.
- Understanding the translation of research evidence into clinical practice for VAP prevention is essential for improving patient care.
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