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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...

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Related Experiment Video

Updated: Jul 2, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Community-associated methicillin-resistant Staphylococcus aureus, eastern Argentina.

Noella Gardella1, Martha von Specht, Arabela Cuirolo

  • 1Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina.

Diagnostic Microbiology and Infectious Disease
|August 22, 2008
PubMed
Summary

A common methicillin-resistant Staphylococcus aureus (MRSA) clone was identified across healthcare centers in Argentina. This prevalent MRSA strain carries specific genes associated with virulence and resistance.

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Last Updated: Jul 2, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) poses a significant public health threat.
  • Understanding the genetic diversity and epidemiology of MRSA is crucial for effective control strategies.

Purpose of the Study:

  • To characterize the genetic makeup of MRSA isolates from healthcare centers in northeastern and eastern Argentina.
  • To identify predominant MRSA clones and their associated resistance and virulence factors.

Main Methods:

  • Pulsed-field gel electrophoresis (PFGE) was used for initial genotyping of 69 MRSA isolates.
  • Multilocus sequence typing (MLST) and spa typing were performed on representative isolates.
  • Detection of SCCmec type IV and Panton-Valentine leukocidin (PVL) genes.

Main Results:

  • A predominant pulsotype was identified and widely distributed across the studied healthcare centers.
  • This major clone harbored SCCmec type IV, indicating methicillin resistance.
  • The clone also carried Panton-Valentine leukocidin genes, associated with enhanced virulence.
  • MLST and spa typing confirmed the clone belonged to ST5 and spa type 311.

Conclusions:

  • A specific CA-MRSA clone (ST5, spa type 311) is widely disseminated in northeastern and eastern Argentina.
  • This clone possesses genetic determinants (SCCmec IV, PVL) contributing to its resistance and virulence.
  • Findings highlight the need for targeted surveillance and control measures against this prevalent MRSA strain.