Related Experiment Video
Updated: Jul 2, 2026
09:43
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Epstein-Barr virus and Burkitt lymphoma
G Brady1, G J Macarthur, P J Farrell
1Department of Virology, Faculty of Medicine, Imperial College, London, UK.
Postgraduate Medical Journal
|August 22, 2008
Summary
Burkitt lymphoma (BL) is an aggressive cancer. This review explores how MYC gene translocations, Epstein-Barr virus, malaria, and immunodeficiency contribute to BL development and survival.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Burkitt lymphoma (BL) is an aggressive B-cell malignancy with distinct variants.
- The MYC gene translocation is a known critical event in BL pathogenesis.
- Factors contributing to MYC translocation and cell survival are under investigation.
Purpose of the Study:
- To review the mechanisms underlying Burkitt lymphoma development.
- To explore the roles of Epstein-Barr virus, malaria, immunodeficiency, and somatic mutations in BL.
- To understand how these factors facilitate MYC gene translocation and cellular survival.
Main Methods:
- Literature review of existing research on Burkitt lymphoma.
- Analysis of the molecular mechanisms involved in MYC gene translocation.
- Examination of the interplay between infectious agents, immune status, and genetic mutations in BL.
Main Results:
- Identified key contributing factors to Burkitt lymphoma, including Epstein-Barr virus infection, malaria endemicity, and immunodeficiency.
- Detailed the mechanisms by which these factors promote MYC gene translocation.
- Highlighted the importance of cellular survival pathways in the context of constitutive MYC expression.
Conclusions:
- Burkitt lymphoma arises from a complex interplay of genetic predisposition and environmental factors.
- Epstein-Barr virus, malaria, and immunodeficiency are significant cofactors in BL pathogenesis.
- Understanding these mechanisms is crucial for developing targeted therapies for Burkitt lymphoma.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...