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Normal glucose values are associated with a lower risk of mortality in hospitalized patients

Alberto Bruno1, Dario Gregori, Antonio Caropreso

  • 1Diabetologia ASO San Giovanni Battista of Turin, Turin, Italy. abruno@molinette.piemonte.it

Diabetes Care
|August 22, 2008
PubMed

Insights

Hospitalized patients with hyperglycemia or hypoglycemia face higher mortality risks. Maintaining plasma glucose levels between 78 and 101 mg/dl is associated with lower mortality, highlighting the importance of glycemic control.

Area of Science:

  • Clinical Medicine
  • Endocrinology
  • Public Health

Background:

  • Hyperglycemia is a prevalent condition among hospitalized individuals.
  • Glycemic status upon admission is a critical factor in patient outcomes.

Purpose of the Study:

  • To investigate the association between admission glycemia and mortality in a diverse adult patient population.
  • To identify specific glycemic ranges linked to increased or decreased mortality risk.

Main Methods:

  • A matched case-control study utilizing 3-year hospital records and plasma glucose data.
  • Involved 3,338 case-control subject pairs, matched by diagnosis-related groups and mortality risk.
  • Multivariate conditional logistic regression analysis was employed to assess glycemia-mortality associations.

Main Results:

  • Elevated in-hospital mortality rates were observed in patients with hyperglycemia or hypoglycemia.
  • A reduced mortality risk was identified for patients with plasma glucose levels between 78 and 101 mg/dl.
  • The study confirms a significant relationship between admission glycemia and patient survival.

Conclusions:

  • Admission glycemia levels are significantly correlated with in-hospital mortality.
  • Both moderately elevated and decreased plasma glucose levels upon admission are associated with increased mortality risk.
  • These findings underscore the importance of monitoring and managing glycemic control in hospitalized patients.
Abstract

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