Chronic Kidney Disease Japan Cohort (CKD-JAC) study: design and methods

Area of Science:

• Nephrology
• Cardiology
• Public Health

Background:

• Japan has the highest prevalence and third highest incidence of end-stage renal disease (ESRD) globally.
• Approximately 20% of Japan's adult population has chronic kidney disease (CKD), defined by an estimated glomerular filtration rate (GFR) < 60 mL/min/1.73 m².
• Nationwide data on ESRD and cardiovascular disease (CVD) risks within the Japanese CKD population are lacking.

Purpose of the Study:

• To establish the Chronic Kidney Disease Japan Cohort (CKD-JAC) with 3,000 CKD patients across 17 centers.
• To determine the incidence of ESRD and CVD in Japanese CKD patients.
• To examine risk factors for CVD, the impact of diabetes comorbidity on CKD progression and CVD incidence, and CKD's effect on quality of life (QOL), hospitalization, and healthcare resource utilization.

Main Methods:

• Establishment of the CKD-JAC observational study.
• Enrollment of 3,000 patients with CKD.
• Data collection on ESRD, CVD incidence, risk factors, diabetes comorbidity, QOL, hospitalization, and healthcare resource utilization.

Main Results:

• The CKD-JAC study is currently being established.
• Data on ESRD and CVD incidence, risk factors, and patient outcomes are pending analysis.

Conclusions:

• The CKD-JAC study will provide crucial insights into the risks and burden of CKD in Japan.
• Findings will inform future interventional trials aimed at reducing ESRD and CVD in this population.