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Related Experiment Video

Updated: Jul 2, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Disseminated intravascular coagulation: current concepts.

R Kumar¹, V Gupta

¹Department of Medical Oncology/Hematology, Cancer Care Manitoba, University of Manitoba, Winnipeg, MB, Canada, R3E, OVN. rajatkr@hotmail.com

Indian Journal of Pediatrics

|August 22, 2008

Summary

This summary is machine-generated.

Disseminated intravascular coagulation (DIC) is a complex acquired disorder disrupting hemostasis, causing widespread clotting and organ damage. Treatment focuses on addressing the underlying cause and replacing clotting factors.

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Published on: May 24, 2020

Area of Science:

Hematology
Pathophysiology
Internal Medicine

Background:

Disseminated intravascular coagulation (DIC) is a critical acquired condition characterized by the disruption of normal hemostatic balance.
It involves excessive thrombin generation, leading to microvascular fibrin deposition and subsequent ischemic organ damage.
The etiology of DIC is multifactorial, stemming from various medical, surgical, oncological, and obstetrical conditions.

Purpose of the Study:

To review the pathophysiology, diagnosis, and management of disseminated intravascular coagulation (DIC).
To discuss the multifactorial etiology and clinical presentation of DIC.
To explore current and potential therapeutic strategies for DIC.

Main Methods:

Diagnosis relies on clinical assessment supported by laboratory parameters.
A scoring system based on laboratory findings aids in diagnosis.
Literature review of existing studies and treatment guidelines.

Main Results:

DIC is triggered by diverse underlying conditions, necessitating prompt recognition.
Laboratory parameters and clinical scoring are crucial for diagnosis.
Treatment primarily involves addressing the causative factor and providing hemostatic support.

Conclusions:

Effective management of DIC requires early diagnosis and treatment of the underlying cause.
Hemostatic support through factor replacement is a cornerstone of therapy.
The role of adjunctive therapies like heparin, antithrombin III, and activated protein C warrants consideration.