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Prevalence of celiac disease in Turkish children with autoimmune thyroiditis

Sinan Sari1, Ediz Yesilkaya, Odul Egritas

  • 1Department of Pediatric Gastroenterology, Faculty of Medicine, Gazi University, 1. Kat, Besevler, Ankara, 06500, Turkey. drsinansari@yahoo.com

Digestive Diseases and Sciences
|August 22, 2008
PubMed

Insights

Celiac disease (CD) is more common in Turkish children with autoimmune thyroiditis (AT). Routine screening for CD is recommended in these pediatric patients to improve early diagnosis.

Area of Science:

  • Pediatric Gastroenterology
  • Autoimmunology
  • Clinical Research

Background:

  • Celiac disease (CD) frequently co-occurs with other autoimmune disorders in both pediatric and adult populations.
  • Autoimmune thyroiditis (AT) is a common autoimmune condition in children, and its association with CD warrants further investigation.

Purpose of the Study:

  • To investigate the prevalence of celiac disease (CD) in a cohort of Turkish children diagnosed with autoimmune thyroiditis (AT).
  • To compare the CD prevalence in children with AT against a control group of healthy children.

Main Methods:

  • Sera from 101 Turkish children with AT and 103 healthy children were screened for IgA anti-tissue transglutaminase (IgA anti-tTG) antibodies and total serum IgA.
  • Small intestinal biopsies were performed for antibody-positive individuals to confirm CD diagnosis.
  • Selective IgA deficiency was assessed in both patient and control groups.

Main Results:

  • The prevalence of positive IgA anti-tTG antibodies was significantly higher in children with AT (7.9%) compared to healthy controls (0%).
  • Subtotal villous atrophy, indicative of CD, was confirmed in 4.9% of the children with AT.
  • No cases of selective IgA deficiency were identified in either group.

Conclusions:

  • The prevalence of celiac disease is elevated in Turkish children with autoimmune thyroiditis.
  • Routine screening for celiac disease is advisable in pediatric patients diagnosed with autoimmune thyroiditis.

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