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Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Updated: Jul 2, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Pattern recognition at the maternal-fetal interface.

Vikki M Abrahams¹

¹Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA. vikki.abrahams@yale.edu

Immunological Investigations

|August 22, 2008

Summary

This summary is machine-generated.

Pattern recognition receptors in the maternal-fetal interface help control intrauterine infections. However, their innate immune responses can cause excessive inflammation, impacting pregnancy outcomes.

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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Last Updated: Jul 2, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Area of Science:

Immunology
Reproductive Biology
Infectious Diseases

Background:

Intrauterine infections pose significant risks to fetal development and pregnancy.
Non-immune cells at the maternal-fetal interface utilize pattern recognition receptors (PRRs) to detect microbes.
These innate immune responses, while protective, can also trigger harmful inflammation and apoptosis.

Purpose of the Study:

To review the current understanding of PRRs, specifically Toll-like receptors (TLRs) and NOD-like receptors (NLRs), in managing intrauterine infections.
To explore the impact of PRR function on pregnancy complications related to infection.

Main Methods:

Literature review of recent studies on PRRs at the maternal-fetal interface.
Analysis of the role of TLRs and NLRs in infection control during pregnancy.
Discussion of the implications of PRR-mediated inflammation and apoptosis.

Main Results:

PRRs are crucial for recognizing and responding to microbial threats during pregnancy.
Dysregulated PRR signaling can lead to excessive inflammation and apoptosis, negatively affecting pregnancy outcomes.
TLRs and NLRs play a dual role: pathogen control and potential harm.

Conclusions:

Pattern recognition receptors are central to the maternal-fetal immune response to infection.
Understanding PRR function is vital for addressing infection-related pregnancy complications.
Targeting PRR pathways may offer therapeutic strategies for improving pregnancy outcomes.