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Related Experiment Video

Updated: Jul 2, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

NKT cells at the maternal-fetal interface.

J E Boyson¹, I Aktan, D A Barkhuff

¹Department of Surgery, University of Vermont College of Medicine, Burlington, Vermont 05405, USA. jboyson@uvm.edu

Immunological Investigations

|August 22, 2008

Summary

Natural killer T (NKT) cells are crucial immune cells at the maternal-fetal interface. Their role in pregnancy is significant, impacting fetal development and maternal health.

Area of Science:

Immunology
Reproductive Biology
Cellular Biology

Background:

The maternal-fetal interface involves immune cell infiltration, including NK cells, macrophages, and T cells.
Decidual T cell function remains less understood compared to NK cells.
NKT cells are a unique T cell subset producing Th1 and Th2 cytokines.

Purpose of the Study:

To review NKT cell biology.
To summarize current literature on NKT cells at the maternal-fetal interface.
To highlight the role of NKT cells in pregnancy.

Main Methods:

Review of existing scientific literature.
Analysis of NKT cell biology and function.
Examination of CD1d molecule's role in NKT cell recognition.

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Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

Related Experiment Videos

Last Updated: Jul 2, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

Main Results:

NKT cells recognize glycolipids via CD1d, distinct from conventional T cells.
NKT cells and CD1d are present at the maternal-fetal interface.
NKT cell activation significantly influences pregnancy outcomes.

Conclusions:

NKT cells play a critical role in regulating the maternal-fetal interface.
Understanding NKT cell function is vital for comprehending pregnancy dynamics.
Further research into NKT cells can offer insights into pregnancy complications.