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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endophthalmitis caused by Citrobacter species
Kuan-Jen Chen1, Ming-Hui Sun, Yih-Shiou Hwang
1Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine Kwei-Shan, Taoyuan, Taiwan. cgr999chiayi@yahoo.com.tw
Ocular Immunology and Inflammation
|August 22, 2008
Summary
Citrobacter endophthalmitis, an eye infection, often leads to poor vision despite antibiotic treatment. Early detection and management are crucial for better visual outcomes and to avoid evisceration.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Endophthalmitis is a serious intraocular infection that can lead to vision loss.
- Citrobacter species are Gram-negative bacteria that can cause opportunistic infections.
Observation:
- This study reviewed 6 cases of endophthalmitis caused by Citrobacter freundii or Citrobacter koseri.
- Infections occurred after various ocular surgeries (cataract, trabeculectomy, keratoplasty), trauma, or from endogenous sources.
- Three patients required evisceration, and five had no light perception vision.
Findings:
- Citrobacter endophthalmitis demonstrated poor visual outcomes, with 5 out of 6 patients experiencing no light perception.
- One case of traumatic Citrobacter koseri endophthalmitis achieved a final visual acuity of 20/30.
- Antibiotic sensitivity patterns varied, but outcomes remained poor despite appropriate treatment.
Implications:
- Early diagnosis and prompt management of Citrobacter endophthalmitis are critical for improving visual prognosis.
- Aggressive treatment may help prevent severe vision loss and the need for evisceration.
- Understanding the clinical spectrum and outcomes is vital for ophthalmologists managing these challenging infections.
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