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Updated: Jul 2, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
Influence of pre-systemic modifications on the drug performance
Z Vitková1, J Oremusová, A Vitko
1Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
Abstract:
Influences of technological and other pre-systemic modifications on the drug performance play a pivotal role in drug development and optimization. The paper evaluates these influences within a framework of the sensitivity theory. Deviations of the drug performance that were caused by modified pre-systemic parameters are predicted and compared with those obtained in vivo. A close correspondence between them demonstrates feasibility of the approach presented and its usability as an alternative or suplementary means of the in vitro-in vivo correlation analysis.
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