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Updated: Jul 2, 2026
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Infantile-onset cutaneous T-cell lymphoma
A Tsianakas1, A K Kienast, P H Hoeger
1Department of Dermatology, University of Hamburg, and Department of Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.
The British Journal of Dermatology
|August 23, 2008
Summary
Diagnosing cutaneous T-cell lymphoma (CTCL) in children is often delayed, especially in infants. Early consideration of CTCL in chronic skin conditions is crucial for timely diagnosis in pediatric patients.
Area of Science:
- Dermatology
- Pediatric Oncology
- Hematology
Background:
- Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL), primarily affects adults.
- Pediatric cases of CTCL are rare, necessitating a review of existing literature.
Observation:
- A literature review identified 254 pediatric CTCL cases (age <16 years).
- Only seven CTCL cases were reported in infants under one year old.
- The youngest age group (0-3 years) experienced the longest diagnostic delay.
Findings:
- CTCL prevalence in children peaks between ages 10-12 years.
- Diagnostic delays in pediatric CTCL decrease with increasing patient age.
- Delayed diagnosis is most pronounced in the youngest pediatric patients.
Implications:
- CTCL diagnosis is frequently delayed in young children.
- Consider CTCL in infants and children with chronic 'eczematous' skin lesions.
- Increased awareness of CTCL is needed for pediatric skin conditions regardless of age.
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