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Published on: October 14, 2021

Infantile-onset cutaneous T-cell lymphoma

A Tsianakas1, A K Kienast, P H Hoeger

  • 1Department of Dermatology, University of Hamburg, and Department of Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.

The British Journal of Dermatology
|August 23, 2008
PubMed

Insights

Diagnosing cutaneous T-cell lymphoma (CTCL) in children is often delayed, especially in infants. Early consideration of CTCL in chronic skin conditions is crucial for timely diagnosis in pediatric patients.

Area of Science:

  • Dermatology
  • Pediatric Oncology
  • Hematology

Background:

  • Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL), primarily affects adults.
  • Pediatric cases of CTCL are rare, necessitating a review of existing literature.

Observation:

  • A literature review identified 254 pediatric CTCL cases (age <16 years).
  • Only seven CTCL cases were reported in infants under one year old.
  • The youngest age group (0-3 years) experienced the longest diagnostic delay.

Findings:

  • CTCL prevalence in children peaks between ages 10-12 years.
  • Diagnostic delays in pediatric CTCL decrease with increasing patient age.
  • Delayed diagnosis is most pronounced in the youngest pediatric patients.

Implications:

  • CTCL diagnosis is frequently delayed in young children.
  • Consider CTCL in infants and children with chronic 'eczematous' skin lesions.
  • Increased awareness of CTCL is needed for pediatric skin conditions regardless of age.
Abstract

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