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Updated: Jul 2, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Cutaneous blastomycosis: a diagnostic challenge.

Ashley R Mason¹, Gil Y Cortes, Joel Cook

¹Department of Dermatology, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

International Journal of Dermatology

|August 23, 2008

Summary

This summary is machine-generated.

Primary cutaneous inoculation blastomycosis is rare. Distinguishing it from secondary cutaneous blastomycosis, often from subclinical lung infections, presents diagnostic challenges, as illustrated by two case studies.

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Last Updated: Jul 2, 2026

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

Area of Science:

Mycology
Dermatology
Infectious Diseases

Background:

Blastomycosis is a fungal infection caused by *Blastomyces dermatitidis*.
Cutaneous blastomycosis can be primary (direct inoculation) or secondary (disseminated from a pulmonary focus).
Secondary cutaneous blastomycosis often arises from subclinical pulmonary infections.

Observation:

Two cases are presented highlighting diagnostic difficulties in differentiating primary inoculation versus secondary cutaneous blastomycosis.
The clinical presentation of cutaneous lesions can be similar in both primary and secondary forms.
The review encompasses over a century of literature on blastomycosis.

Findings:

Distinguishing primary cutaneous inoculation blastomycosis from secondary involvement is clinically challenging.
Secondary cutaneous blastomycosis frequently originates from asymptomatic pulmonary infections.
The study underscores the importance of considering both routes of cutaneous involvement.

Implications:

Improved diagnostic criteria are needed to differentiate primary and secondary cutaneous blastomycosis.
Early recognition of cutaneous blastomycosis is crucial for timely treatment.
Further research into the pathogenesis and clinical manifestations of blastomycosis is warranted.