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[Frequency of ABO type IgM antibody in 276 infants younger than six months]
Shu-Xuan Ma1, Xi-Wei Xu, Wen-Qi Song
1Laboratory Center of Beijing Children Hospital, Capital Medical University, Beijing 100045, China. masxfwyy@sina.com
Insights
ABO type IgM antibodies are frequently detected in infants under six months old. This finding supports their use as crucial evidence for accurate ABO blood typing in this pediatric population.
Area of Science:
- Immunology
- Pediatrics
- Hematology
Context:
- Infant blood typing can be challenging due to the potential absence of ABO antibodies.
- Understanding antibody development in early life is critical for transfusion safety and clinical diagnostics.
Purpose:
- To investigate the prevalence and consistency of ABO type IgM antibodies in infants younger than six months.
- To evaluate the utility of these IgM antibodies for reliable ABO blood group determination in neonates and infants.
Summary:
- This study analyzed 309 infants under six months, categorizing them into five age groups. ABO blood typing was performed using standard serological methods.
- Results showed ABO type IgM antibodies were present in a significant proportion of infants, with a notably higher consistency rate (85%) in the 4-6 month age group.
Impact:
- The findings suggest that ABO type IgM antibodies are a reliable indicator for ABO typing in infants.
- This research provides valuable data for improving diagnostic accuracy and clinical management in pediatric hematology.
Abstract:
The aim of study was to explore the frequency of ABO type IgM antibody in infants younger than six months. 309 hospitalized infants younger than six months were selected at first and their EDTA K(3) anticoagulant blood samples were taken. All the infants were divided into five groups: neonates within 1 week as group I; neonates aged 8 to 14 days as group II; neonates aged 15 days to 1 month as group III; infants aged two to 3 months as group IV and infants aged 4 to 6 months as group V. The monocolonal anti-A, anti-B serums, A cells, B cells and O cells were utilized to carried out the blood typing with tube test. The results indicated that from 309 samples tested 33 AB type sample were excluded. Out of the remains of 276 samples, 29 of 46 samples in group I were positive and with the ABO type consistent rate 63% (29/46); 41 of 64 samples in group II were positive and with the ABO type consistent rate 64% (41/64); 47 of 74 samples in group III were positive and with the ABO type consistent rate 63% (47/74); 28 of 45 samples in group IV were positive and with the ABO type consistent rate 62% (28/45); 40 of 47 samples in group V were positive and with the ABO type consistent rate 85%. It is concluded that the ABO type IgM antibody appear in most infants younger than six months and these IgM antibodies may be regarded as the important evidence for ABO typing in infants.
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