Brooke-Spiegler syndrome: report of a case of multiple cylindromas and trichoepitheliomas
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06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Sean D Doherty1, Terry L Barrett, Aaron K Joseph
1Baylor College of Medicine, Houston, Texas, USA.
Dermatology Online Journal
|August 23, 2008
Abstract:
We report a case of Brooke-Spiegler syndrome, a rare autosomal dominant disorder caused by mutations of the cylindromatosis gene (CYLD) tumor suppressor gene resulting in multiple cylindromas and trichoepitheliomas. Treatment of these patients can involve surgical excision, laser therapy, or topical applications of aspirin derivatives.
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