Related Experiment Video
Updated: Jul 2, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Chromosomal translocations in cancer
Mridula Nambiar1, Vijayalakshmi Kari, Sathees C Raghavan
1Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.
Chromosomal translocations are key genetic alterations causing cancers like leukemia and lymphoma. Understanding their formation and impact is crucial for cancer diagnosis and developing new therapies.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Genetic alterations, including deletions, inversions, and chromosomal translocations, can drive cancer development by affecting critical genes like proto-oncogenes and tumor suppressor genes.
- Chromosomal translocations are particularly significant, serving as primary drivers for various cancers such as lymphoma, leukemia, and certain solid tumors.
Purpose of the Study:
- To review well-established chromosomal translocations implicated in human cancers.
- To discuss recent advancements in understanding the mechanisms behind chromosomal translocation formation.
Main Methods:
- Literature review of established chromosomal translocations in cancer.
- Synthesis of current research on the mechanisms of translocation formation.
Main Results:
- Chromosomal translocations can lead to gene fusions or altered gene expression by repositioning genes near regulatory elements.
- These translocations are valuable diagnostic markers and therapeutic targets in oncology.
Conclusions:
- Chromosomal translocations play a pivotal role in oncogenesis and cancer progression.
- Continued research into translocation mechanisms is essential for improving cancer diagnostics and therapeutics.
More Related Videos
09:40Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
Published on: September 23, 2011
10:34Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR
Published on: February 1, 2013
Related Concept Videos
Cancers Originate from Somatic Mutations in a Single Cell
Cancers Originate from Somatic Mutations in a Single Cell
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...