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Updated: Mar 4, 2026

Author Spotlight: A Focus on Standardized Salivary Gland Ultrasound Protocol in Connective Tissue Disease Research
Published on: October 13, 2023
The effects of high frequency, low intensity ultrasound therapy on parotid flow rates
Vidya Sankar1, Thomas Prihoda, Geza Terezhalmy
1Department of Dental Diagnostic Science, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. sankarv@uthscsa.edu
Objectives:
Saliva plays a critical role in maintaining oral health and comfort. Development of a single device capable of simulating salivary flow with no taste or adverse side effects is desirable.
Study Design:
This clinical investigation on 23 healthy volunteers with no dry mouth complaints evaluated the effectiveness of ultrasonic therapy in mechanical stimulation of the parotid gland to increase saliva flow. Stimulated and unstimulated parotid saliva was collected. Differences in mean salivary flow rates and affects of age and ethnicity were measured.
Results:
The mean difference between stimulated and unstimulated saliva flow rates was 0.009 mL/min +/- SD = 0.042, t (df = 22) = 1.27 with P = .31. There were no significant differences of age (P = .26), gender (P = .38), or race/ethnicity (P = .58) for the difference of stimulated and unstimulated conditions.
Conclusions:
Results indicate that high-frequency low-intensity ultrasound therapy is not effective in stimulating salivary flow rates.
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