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Published on: August 15, 2025
Intraoral superficial angiomyxoma
1Division of Oral Pathology, University of Witwatersrand, Johannesburg, South Africa. shabnum.meer@nhls.ac.za
Summary
Superficial angiomyxoma, a rare benign tumor, can occur in the mouth. This case highlights its presence in the buccal mucosa, emphasizing its inclusion in differential diagnoses for intraoral myxoid neoplasms.
Area of Science:
- Oral pathology
- Dermatopathology
- Surgical oncology
Background:
- Superficial angiomyxoma is a rare, benign myxoid tumor typically found on the trunk, head and neck, extremities, and genitalia.
- Intraoral occurrences are exceptionally uncommon, with limited documented cases.
Observation:
- A 37-year-old woman presented with a symptomless, slow-growing mass in her buccal mucosa, present for two years.
- Histopathological examination revealed a lobulated, paucicellular myxoid tumor with significant vascularity and stromal inflammation.
Findings:
- Immunohistochemical analysis showed positivity for CD34, vimentin, and muscle-specific actin.
- The tumor exhibited features consistent with superficial angiomyxoma, despite its intraoral location.
Implications:
- This case confirms that superficial angiomyxoma can manifest intraorally, specifically in the buccal mucosa.
- It should be considered in the differential diagnosis of intraoral soft tissue neoplasms with myxoid characteristics.
- Localized excision is curative, though follow-up is advised due to the high recurrence rate of cutaneous counterparts.
