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Ultrastructural study of mitochondria in oncocytes
1Department of Otorhinolaryngology, Nara Medical University, Kashihara, Nara, Japan.
Ultrastructural Pathology
|May 1, 1991
Summary
Mitochondria in oncocytes exhibit pleomorphism. Their complex 3D structures, including cup-shaped forms and aberrant cristae, arise from invagination and laminated cristae modifications.
Area of Science:
- Oncology
- Cell Biology
- Electron Microscopy
Background:
- Mitochondria in oncocytes often display variations in shape and internal structure.
- Conventional electron microscopy suggests mitochondrial pleomorphism in oncocytes.
Purpose of the Study:
- To investigate the three-dimensional (3D) stereostructure of mitochondria in oncocytes.
- To elucidate the origins of mitochondrial pleomorphism and aberrant cristae in Warthin's tumor.
Main Methods:
- Analysis of serial thin sections from 11 Warthin's tumor specimens.
- Stereostructural investigation using advanced electron microscopy techniques.
Main Results:
- Cup-shaped and concentric ring mitochondrial forms are a result of mitochondrial invagination.
- Abnormal cristae, including sheaflike and vesicular types, originate from laminated cristae with vesicular structures.
Conclusions:
- The observed mitochondrial pleomorphism in oncocytes is attributed to specific structural rearrangements.
- Understanding these mitochondrial alterations provides insights into oncocyte biology within Warthin's tumors.