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Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...

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Related Experiment Video

Updated: Jul 2, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

Cell death specification in C. elegans.

Erin Peden1, Darrell J Killian, Ding Xue

  • 1Department of Molecular, University of Colorado at Boulder, Boulder, Colorado 80309, USA. erin.peden@colorado.edu

Cell Cycle (Georgetown, Tex.)
|August 23, 2008
PubMed
Summary
This summary is machine-generated.

Investigating cell death in C. elegans reveals that transcriptional regulation of egl-1 and ced-3 is key for specifying apoptosis. Further research is needed to explore additional cell death specification mechanisms.

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Isolation of Specific Neuron Populations from Roundworm Caenorhabditis elegans
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Isolation of Specific Neuron Populations from Roundworm Caenorhabditis elegans

Published on: August 6, 2019

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Last Updated: Jul 2, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

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Published on: August 15, 2020

Isolation of Specific Neuron Populations from Roundworm Caenorhabditis elegans
09:42

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Published on: August 6, 2019

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Apoptotic cell killing is a conserved biological process.
  • The precise mechanisms specifying which cells undergo apoptosis remain largely unknown.
  • The nematode C. elegans is a valuable model organism for studying programmed cell death due to its invariant cell death events.

Purpose of the Study:

  • To summarize current knowledge on cell death specification in C. elegans.
  • To identify factors involved in specifying individual cell death events.
  • To explore potential additional modes of cell death specification.

Main Methods:

  • Review of recent genetic studies on cell death specification in C. elegans.
  • Analysis of transcriptional regulation of core cell death pathway genes (egl-1, ced-3).

Main Results:

  • Genetic studies have identified diverse factors regulating cell death specification.
  • Findings suggest transcriptional regulation of egl-1 and ced-3 is a primary mechanism.
  • The existence of other cell death specification pathways is still under investigation.

Conclusions:

  • Cell death specification in C. elegans involves transcriptional control of key apoptotic genes.
  • Further investigation is required to fully understand the complexity of cell death specification pathways.