[Raising HDL cholesterol: which is the best strategy?]

Area of Science:

• Cardiology
• Metabolic Disorders
• Preventive Medicine

Background:

• Low-density lipoprotein (LDL) cholesterol targets are often achieved first in cardiovascular risk management.
• High-density lipoprotein (HDL) cholesterol possesses known anti-atherogenic properties, supported by epidemiological evidence.
• Improving HDL cholesterol is a critical, yet often secondary, objective in managing cardiovascular disease (CVD).

Purpose of the Study:

• To review current clinical strategies for increasing high-density lipoprotein (HDL) cholesterol levels.
• To provide a concise overview of therapeutic alternatives for enhancing HDL cholesterol in patient care.
• To support the achievement of better clinical outcomes regarding cardiovascular morbidity and mortality.

Main Methods:

• Systematic review of clinical practice guidelines and relevant literature.
• Analysis of pharmacological and non-pharmacological interventions aimed at raising HDL cholesterol.
• Synthesis of evidence on the efficacy and applicability of different HDL-raising strategies.

Main Results:

• Multiple therapeutic avenues exist to increase HDL cholesterol in clinical settings.
• Interventions range from lifestyle modifications to specific drug classes.
• The review consolidates practical approaches for clinicians to manage HDL levels effectively.

Conclusions:

• Optimizing HDL cholesterol is a vital component of comprehensive cardiovascular disease prevention.
• Clinicians have various evidence-based options to effectively raise HDL cholesterol levels.
• Targeting HDL cholesterol contributes to improved patient outcomes and reduced cardiovascular events.