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Updated: Jul 2, 2026
09:07
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Is there a role for mast cells in psoriasis?
Ilkka T Harvima1, Gunnar Nilsson, Mireille-Maria Suttle
1Department of Dermatology, Kuopio University Hospital and University of Kuopio, P O. Box 1777, 70211, Kuopio, Finland. ilkka.harvima@kuh.fi
Archives of Dermatological Research
|August 23, 2008
Summary
Mast cells are key players in immunity and inflammation, not just allergies. This review explores their complex role in skin inflammation and conditions like psoriasis.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Mast cells, traditionally viewed as allergic effectors, are now recognized for their crucial roles in innate and acquired immunity.
- Activated mast cells release diverse mediators (cytokines, chemokines, histamine) and express surface molecules (MHC class II, co-stimulatory ligands) that influence immune cell interactions.
Purpose of the Study:
- To review the multifaceted roles of mast cells in immune responses and skin inflammation.
- To discuss the specific involvement of mast cells in the pathogenesis of psoriasis.
Main Methods:
- Literature review focusing on mast cell activation, mediator release, and cell surface molecule expression.
- Analysis of mast cell involvement in inflammatory skin conditions, particularly psoriasis.
Main Results:
- Mast cells contribute to skin inflammation by interacting with various cells and releasing inflammatory mediators.
- In psoriasis, tryptase- and chymase-positive mast cells are activated early, increase in number, and interact with sensory nerves.
Conclusions:
- Mast cells are integral to immune responses and skin inflammation, with complex pro- and anti-inflammatory functions.
- Their early activation and sustained presence in psoriatic lesions highlight their significant role in disease pathogenesis.
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