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Alcohol affects otolith-induced ocular counterrolling: dosage effects.

Shirley G Diamond¹, Charles H Markham

¹Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106, USA.

Acta Oto-Laryngologica

|August 23, 2008

Summary

Alcohol significantly impacts otolith function, with higher doses causing greater impairment. This study compared the effects of 5 oz versus 3 oz of alcohol on ocular counterrolling (OCR).

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Area of Science:

Neuroscience
Ophthalmology
Vestibular System

Background:

Alcohol consumption is known to affect neurological functions.
Ocular counterrolling (OCR) is a reflex mediated by the otolith organs, sensitive to alcohol's effects.
Previous research indicated that 3 oz of alcohol impaired OCR amplitude and smoothness.

Purpose of the Study:

To investigate the dose-dependent effects of alcohol on ocular counterrolling (OCR).
To compare the impact of a 5 oz alcohol dose with a previously studied 3 oz dose on OCR parameters.

Main Methods:

Twenty healthy subjects participated in the study.
Ocular counterrolling (OCR) tests were performed before and after alcohol consumption.
Subjects ingested 5 oz of 80 proof vodka, with resulting blood alcohol levels (BAL) monitored.

Main Results:

A 5 oz alcohol dose led to significantly reduced OCR amplitude and increased disconjugacy.
In contrast, a 3 oz dose resulted in reduced amplitude, but improved smoothness and no change in disconjugacy.
Higher blood alcohol levels (0.09-0.18%) from the 5 oz dose caused greater impairment than lower levels (0.04-0.09%) from the 3 oz dose.

Conclusions:

Alcohol ingestion significantly impairs otolith-dependent ocular counterrolling (OCR).
The negative effects of alcohol on OCR amplitude and disconjugacy are dose-dependent.
Higher alcohol doses abolish the smoothness benefits observed with lower doses, indicating greater vestibular disruption.