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Published on: September 20, 2016
In vitro evaluation of theophylline matrices using xyloglucan.
1School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico 00936-5067, USA.
This study explored xyloglucan, a tamarind polysaccharide, for oral sustained release matrices. The best formulation demonstrated controlled theophylline release, suggesting potential for drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Polymer Science
Background:
- Xyloglucan, a water-soluble polysaccharide from Tamarindus Indica beans, has limited research regarding its application in oral sustained-release swellable matrices.
- Developing novel polymeric matrices is crucial for controlled drug delivery systems.
Purpose of the Study:
- To formulate and evaluate sustained-release matrices using xyloglucan.
- To investigate the influence of polymer concentration, diluents, and dissolution medium characteristics on drug release kinetics.
- To determine the drug release mechanism from xyloglucan-based swellable matrices.
Main Methods:
- Tablet formulations were prepared using theophylline as a model drug, varying xyloglucan concentrations (20-40%) and diluents (Avicel PH-101, lactose, dibasic calcium phosphate).
- Theophylline release was assessed under different conditions, including varying polymer levels, dissolution media (pH, ionic strength), and basket rotational speeds.
- Swelling isotherms were studied to understand matrix behavior.
Main Results:
- The optimal formulation (30% xyloglucan, Avicel PH-101) exhibited controlled theophylline release (34.2% at 6 hours).
- Increasing xyloglucan concentration significantly impacted drug release rates (p<0.05).
- Diluent type, dissolution medium variations, and basket speed showed no significant effect on drug release.
Conclusions:
- Xyloglucan is a viable polymer for developing oral sustained-release swellable matrices.
- The drug release mechanism from these matrices appears to follow anomalous relaxation.
- Further research into xyloglucan-based drug delivery systems is warranted.
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