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Updated: Jul 2, 2026

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy
07:05

Visualization of Neutrophil Extracellular Traps in Mesenteric Venules After Mesenteric Ischemia-Reperfusion Injury via Intravital Microscopy

Published on: September 27, 2024

Epidemiology, risk and prognostic factors in mesenteric venous thrombosis

S Acosta1, A Alhadad, P Svensson

  • 1Vascular Centre, Malmö University Hospital, Malmö, Sweden. stefan.acosta@telia.com

The British Journal of Surgery
|August 23, 2008
PubMed
Abstract

Insights

Mesenteric venous thrombosis (MVT) is rare, with highest incidence in older adults. Activated protein C resistance is a key risk factor, suggesting lifelong anticoagulation may be beneficial for MVT patients.

Area of Science:

  • Vascular Surgery
  • Gastroenterology
  • Hematology

Background:

  • Epidemiological data on mesenteric venous thrombosis (MVT) risk and prognostic factors are limited.
  • Mesenteric venous thrombosis (MVT) affects predominantly older individuals, with the highest incidence observed in the 70-79 age group.

Purpose of the Study:

  • To investigate the incidence, risk factors, diagnostic methods, and outcomes of mesenteric venous thrombosis (MVT).

Main Methods:

  • Retrospective analysis of 51 patients diagnosed with mesenteric venous thrombosis (MVT) between 2000 and 2006.
  • Utilized inpatient and autopsy registries; diagnostic modalities included multidetector row computed tomography (CT) and laboratory tests.
  • Evaluated associations between clinical factors, diagnostic methods, and mortality.

Main Results:

  • The incidence of MVT was 11.3 per 100,000 person-years in those aged 70-79.
  • Activated protein C resistance was identified in 13/29 patients tested; D-dimer was elevated in all tested patients.
  • Multidetector row CT in the portal venous phase was highly sensitive for MVT diagnosis; 30-day mortality was 20%, associated with intestinal infarction and lack of CT.
  • Cancer independently predicted long-term mortality.

Conclusions:

  • Portal venous phase CT is a sensitive diagnostic tool for mesenteric venous thrombosis (MVT).
  • Activated protein C resistance is a significant risk factor, warranting consideration for lifelong anticoagulation therapy in MVT patients.

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