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Related Experiment Video

Updated: Jul 2, 2026

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
04:01

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

Published on: June 14, 2024

Severe hydroxychloroquine myopathy.

Hoda Abdel-Hamid1, Chester V Oddis, David Lacomis

  • 1Department of Pediatrics, Division of Child Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Muscle & Nerve
|August 23, 2008
PubMed
Summary
This summary is machine-generated.

Hydroxychloroquine can cause severe muscle damage (myopathy), even leading to fatal respiratory failure. Early recognition of hydroxychloroquine myopathy is crucial for patient outcomes.

Related Experiment Videos

Last Updated: Jul 2, 2026

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
04:01

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

Published on: June 14, 2024

Area of Science:

  • Rheumatology
  • Neurology
  • Toxicology

Background:

  • Hydroxychloroquine is commonly prescribed for autoimmune diseases.
  • Hydroxychloroquine-induced myopathy is typically mild but can be severe.
  • Underrecognition is common, especially with polypharmacy.

Purpose of the Study:

  • To report cases of unusually severe hydroxychloroquine myopathy.
  • To highlight the potential for fatal outcomes.
  • To emphasize the need for early diagnosis.

Main Methods:

  • Case report of two patients with connective tissue diseases.
  • Histopathological confirmation of myopathy.
  • Clinical assessment of disease severity and complications.

Main Results:

  • Both patients presented with severe, histopathologically proven hydroxychloroquine myopathy.
  • Both experienced ventilatory failure.
  • One patient had associated scleroderma-related lung disease; the other did not.

Conclusions:

  • Hydroxychloroquine myopathy can be severe and life-threatening.
  • Ventilatory failure is a potential complication.
  • Prompt recognition and management are essential.