Related Experiment Video
Updated: Jul 2, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
[Effect of several penetration enharcers on transdermal permeation and skin accumulation of artemether]
Jun-Yao He1, Shi-Xiang Hou, Zheng Cai
1West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Objective:
To investigate penetration characteristics of artemether and the effect of different permeation enhancer on transdermal permeation of artemether through rat skin.
Method:
The permeation experiments were performed using rat skin on modified Franz diffusion cells in vitro. The concentrations of artemether in receptor compartment at specified time points were determined by HPLC.
Result:
The permeating ratio through human skin of artemether solution was Js (2.78 +/- 0.78) microg x cm(-2) x h(-1), the quantity of drug penetrated through and accumulated in the skin by the end of the experiment were (69.07 +/- 3.01) microg x cm(-2), (58.93 +/- 3.56) microg x cm(-2) respectively. Four different permeation enhancers can improve the transdermal permeation of artemether.
Conclusion:
Artemether have the potential to be developed to new transdermal preparation.
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