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Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp
Yan Li1, Bingda Sun, Shuchun Liu
1Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Abstract:
Five new asterric acid derivatives, ethyl asterrate (3), n-butyl asterrate (4), and geomycins A-C (6-8), have been isolated from cultures of an isolate of the Antarctic ascomycete fungus Geomyces sp. The structures of these metabolites were elucidated by NMR spectroscopy. The absolute configuration of 8 was determined by application of the CD excitation chirality method. Compound 7 displayed antifungal activity against Aspergillus fumigatus, whereas 8 showed antimicrobial activities against gram-positive and gram-negative bacteria.
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