Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Nov 23, 2025

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.4K

Basic infertility including polycystic ovary syndrome.

Maryse Brassard1, Youssef AinMelk, Jean-Patrice Baillargeon

  • 1Division of Endocrinology, Department of Medicine, Université de Sherbrooke, 3001, 12th North Avenue, Sherbrooke, QC J1H 5N4, Canada.

The Medical Clinics of North America
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender-related perceptions among healthcare providers and mothers in a pregnancy and early childhood obesity prevention intervention in Shanghai, China.

International journal for equity in health·2026
Same author

Sino-Canadian Healthy Life Trajectories Initiative in China: an economic evaluation protocol.

BMJ open·2026
Same author

Antenatal depressive symptoms impair offspring neurodevelopment by inducing maternal gut microbiota dysbiosis during pregnancy.

Gut microbes·2026
Same author

Early secondary outcome analysis in multi-phase randomised-controlled trials, a pragmatic approach: the Healthy Life Trajectories Initiative (HeLTI).

Trials·2026
Same author

Investigating Beliefs Toward Physical Activity in Pregnancy Among Women With and Without Gestational Diabetes Mellitus.

Canadian journal of diabetes·2026
Same author

Outcome evaluation of the Web-based early intervention for children with motor difficulties aged 3-8 years old using multimodal rehabilitation: results of a family-centered pragmatic randomized controlled study.

Disability and rehabilitation·2026

Polycystic Ovary Syndrome (PCOS) is a common cause of infertility in women. Metformin, combined with weight loss, is a safe and effective first-line treatment for PCOS infertility, promoting single ovulation and reducing pregnancy loss.

Area of Science:

  • Reproductive Endocrinology
  • Metabolic Disorders
  • Primary Care Medicine

Background:

  • Polycystic Ovary Syndrome (PCOS) is a leading cause of medically treatable infertility in women.
  • Anovulatory infertility affects 70% of PCOS cases, necessitating effective management in primary care.
  • Obesity exacerbates infertility and adverse pregnancy outcomes in women with PCOS.

Purpose of the Study:

  • To evaluate metformin and lifestyle modifications as a first-line therapy for PCOS-related infertility.
  • To compare the efficacy of metformin with traditional ovulation-inducing drugs.
  • To highlight the benefits of weight loss in improving fertility and pregnancy outcomes.

Main Methods:

  • Systematic approach to diagnosing and managing female infertility.

More Related Videos

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

3.2K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.6K

Related Experiment Videos

Last Updated: Nov 23, 2025

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.4K
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

3.2K
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

11.6K
  • Utilizing insulin sensitization through weight loss or metformin for PCOS treatment.
  • Comparative analysis of metformin versus ovulation-inductor drugs for fertility outcomes.

    • Main Results:

    • Metformin with weight loss is a safe and effective treatment for PCOS infertility.
    • This approach eliminates the risk of multiple pregnancies, unlike ovulation-inductor drugs.
    • Metformin may reduce the risk of early pregnancy loss and promotes normal single ovulation.

    Conclusions:

    • Metformin should be considered a first-line therapy for PCOS infertility.
    • Lifestyle modifications and weight loss are crucial before and during pregnancy.
    • Metformin offers advantages including normal ovulation, reduced pregnancy loss, and improved maternal/fetal outcomes.