Related Experiment Video
Updated: Jul 2, 2026
06:51
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises
Timothy A Yap1, Michelle D Garrett, Mike I Walton
1Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, UK.
Current Opinion in Pharmacology
|August 30, 2008
Summary
Targeting the phosphatidylinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway offers a promising strategy for novel cancer therapeutics. This review highlights progress in developing PI3K-AKT-mTOR pathway inhibitors for cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- The 'drugging the cancer kinome' strategy has yielded successful molecular targeted agents.
- The phosphatidylinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway is a critical target in oncogenesis.
- Understanding this pathway is crucial for developing new cancer therapies.
Purpose of the Study:
- To review the role of the PI3K-AKT-mTOR pathway in cancer.
- To detail the development of novel therapies targeting this pathway.
- To discuss strategies, challenges, and future directions for PI3K-AKT-mTOR pathway inhibitors.
Main Methods:
- Literature review of preclinical and clinical studies.
- Analysis of therapeutic strategies targeting the PI3K-AKT-mTOR pathway.
- Discussion of biomarker utility in patient selection and target modulation.
Main Results:
- Several novel molecular targeted agents have been developed.
- Emphasis on agents that have entered clinical development for cancer treatment.
- Exploration of horizontal and vertical blockade strategies for pathway inhibition.
Conclusions:
- Targeting the PI3K-AKT-mTOR pathway is a key focus for novel cancer therapeutics.
- Biomarkers are essential for patient selection and confirming target modulation.
- Further research is needed to overcome limitations and optimize these anticancer agents.
Related Concept Videos
01:22PI3K/mTOR/AKT Signaling Pathway
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:20The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...