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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jul 2, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Pessin award lecture 2008: lessons from the Stroke PROTECT program.

Bruce Ovbiagele1

  • 1Stroke Center and Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA. Ovibes@mednet.ucla.edu

Journal of the Neurological Sciences
|August 30, 2008
PubMed
Summary

The Stroke PROTECT program improved secondary stroke prevention by coordinating 8 therapies. This led to better treatment use, adherence, and patient outcomes after hospital discharge.

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A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice
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A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice

Published on: May 5, 2023

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Last Updated: Jul 2, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice
04:46

A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice

Published on: May 5, 2023

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Many ischemic stroke and transient ischemic attack patients undertreat vascular risk factors.
  • Effective strategies are needed to improve secondary prevention in cerebrovascular disease.

Purpose of the Study:

  • To present the Stroke PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program.
  • To evaluate its impact on secondary stroke prevention.

Main Methods:

  • Systematic implementation of 8 medication and behavioral secondary prevention measures.
  • Assessment of treatment utilization, adherence, biomarker control, and clinical outcomes.

Main Results:

  • The PROTECT program significantly increased treatment utilization at discharge.
  • It also improved post-discharge adherence, biomarker control, and clinical outcomes.

Conclusions:

  • Coordinated secondary prevention programs like PROTECT enhance evidence-based care for stroke survivors.
  • Further development of empirically derived models is crucial for bridging the knowledge-practice gap in stroke prevention.