Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Whipple's disease].

X Puéchal1

  • 1Service de rhumatologie, Centre hospitalier du Mans, 72037 Le Mans cedex 9, France. xpuechal@ch-lemans.fr

La Revue De Medecine Interne
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Whipple's disease is a curable bacterial infection, often presenting with arthritis before gastrointestinal issues. Early diagnosis using PCR and future antibody tests are crucial for preventing severe outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Large-vessel involvement in ANCA-associated vasculitis: A multicenter case-control study.

Seminars in arthritis and rheumatism·2024
Same author

[Anti-IL-5 in severe asthma associated with eosinophilic granulomatosis with polyangiitis. Real-life study].

Revue des maladies respiratoires·2023
Same author

Off-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis.

European journal of internal medicine·2021
Same author

Renal and overall outcomes of double-positive (ANCA and anti-GBM antibodies) patients compared to ANCA-associated vasculitis patients with severe renal involvement: A multicenter retrospective study with systematic renal pathology analysis.

Scandinavian journal of rheumatology·2021
Same author

Schnitzler syndrome: validation and applicability of diagnostic criteria in real-life patients.

Allergy·2016
Same author

Management of giant cell arteritis: Recommendations of the French Study Group for Large Vessel Vasculitis (GEFA).

La Revue de medecine interne·2016
Same journal

[Abdominal pain, fever and arthralgia in a 49-year-old woman].

La Revue de medecine interne·2026
Same journal

[Cardiorespiratory functional disorders: A transnosologic approach].

La Revue de medecine interne·2026
Same journal

[Diagnostic evaluation for suspected polycythemia].

La Revue de medecine interne·2026
Same journal

Heart involvements in systemic sclerosis beyond pulmonary hypertension: From conduction, rhythm and function defects to coronary artery disease.

La Revue de medecine interne·2026
Same journal

[Acute intermittent porphyria: When diagnostic errance jeopardizes patient health].

La Revue de medecine interne·2026
Same journal

Autosomal dominant polycystic kidney disease: Current perspectives in 2026.

La Revue de medecine interne·2026
See all related articles

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Rheumatology

Background:

  • Whipple's disease is a chronic, multisystemic bacterial infection caused by Tropheryma whipplei.
  • It typically affects middle-aged men and presents with diverse clinical manifestations, often including arthritis preceding gastrointestinal symptoms.

Purpose of the Study:

  • To summarize the clinical presentation, diagnosis, and recent advancements in understanding Whipple's disease.
  • To highlight the importance of considering Whipple's disease in atypical presentations and the potential for earlier diagnosis.

Main Methods:

  • Review of clinical manifestations, diagnostic challenges, and current/emerging diagnostic tools.
  • Discussion of Tropheryma whipplei cultivation, genome sequencing, and potential future diagnostic assays.

Related Experiment Videos

Main Results:

  • Arthritis is a common early symptom, often preceding gastrointestinal issues by years.
  • Diagnosis can be challenging due to variable symptoms and potential for negative jejunum biopsy or PCR results.
  • Tropheryma whipplei has been identified as the causative agent, with PCR being a valuable diagnostic tool.

Conclusions:

  • Whipple's disease requires consideration even without gastrointestinal symptoms, especially in cases of unexplained arthritis, neurological issues, or endocarditis.
  • Recent advancements in T. whipplei research, including cultivation and genome sequencing, offer promise for improved understanding and treatment.
  • Future diagnostic strategies, such as antibody detection and immunohistochemistry, aim for earlier diagnosis to prevent severe, potentially fatal disease stages.