Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 2, 2026

Establishment of Deep Hypothermic Circulatory Arrest in Rats
08:39

Establishment of Deep Hypothermic Circulatory Arrest in Rats

Published on: December 16, 2022

Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia.

Naoto Morimoto1, Keisuke Morimoto, Yoshihisa Morimoto

  • 1Division of Cardiovascular Surgery, Kobe University, Graduate School of Medicine, Kobe, Hyogo, Japan. naotom@med.kobe-u.ac.jp

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|August 30, 2008
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of Ascending Colon Stricture Following Appendicitis with Abscess Formation.

Cureus·2026
Same author

<b>A new species of spined loach from the southern Shikoku Island, Japan (Cypriniformes: Cobitidae)</b>.

Zootaxa·2026
Same author

Size and Macroscopic Type of Type B2 Vessel Areas in JES Classification for Predicting Invasion Depth: A Multicenter Prospective Study.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2026
Same author

Crystalloid cardioplegia versus cold blood cardioplegia in aortic arch surgery: A noninferiority randomized trial.

JTCVS open·2026
Same author

Prognostic Utility of Perivascular Adipose Tissue Attenuation in Patients Undergoing Endovascular Aneurysm Repair for Abdominal Aortic Aneurysms.

Circulation. Cardiovascular imaging·2026
Same author

Scrotal uptake on PSMA PET in prostate cancer: differentiating metastases from benign and physiologic findings using ultrasound correlation.

Abdominal radiology (New York)·2026

Prophylactic sivelestat administration during cardiopulmonary bypass (CPB) improves postoperative pulmonary function in patients undergoing total arch replacement. This leads to better oxygenation and earlier extubation times, enhancing respiratory management.

Area of Science:

  • Cardiovascular Surgery
  • Pulmonary Medicine
  • Pharmacology

Background:

  • Total arch replacement with deep hypothermia and circulatory arrest significantly impacts pulmonary function compared to other cardiac surgeries.
  • Sivelestat sodium hydrate has been administered prophylactically since April 2004 during cardiopulmonary bypass (CPB) for total arch replacement.
  • The study investigates sivelestat's potential to mitigate post-pump pulmonary dysfunction.

Purpose of the Study:

  • To evaluate the efficacy of prophylactic sivelestat administration in preventing pulmonary dysfunction after total arch replacement.
  • To compare postoperative pulmonary function and respiratory parameters between patients who received sivelestat and those who did not.

Main Methods:

  • Retrospective analysis of 120 patients undergoing total arch replacement (August 2001 - December 2006).

Related Experiment Videos

Last Updated: Jul 2, 2026

Establishment of Deep Hypothermic Circulatory Arrest in Rats
08:39

Establishment of Deep Hypothermic Circulatory Arrest in Rats

Published on: December 16, 2022

  • Patients divided into two groups: Group A (n=60) received sivelestat, Group B (n=60) did not.
  • Evaluation of hemodynamic, respiratory, and inflammatory markers up to 48 hours post-surgery.

    • Main Results:

    • No significant differences in baseline characteristics or intraoperative variables between groups.
    • Sivelestat group showed significantly improved respiratory and oxygenation indices (p<0.001).
    • Lower C-reactive protein (CRP) levels (p=0.022) and significantly shorter extubation times (p=0.033) were observed in the sivelestat group.

    Conclusions:

    • Prophylactic sivelestat administration at CPB initiation improves postoperative pulmonary function.
    • Sivelestat facilitates earlier extubation, suggesting its effectiveness in managing respiratory complications after total arch replacement.
    • The drug appears beneficial for postoperative respiratory management in this patient population.