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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...

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Updated: Jul 2, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Vitamin d.

Katie M Dixon1, Rebecca S Mason

  • 1Department of Physiology and Bosch Institute, University of Sydney, NSW 2006 Australia. katied@physiol.usyd.edu.au

The International Journal of Biochemistry & Cell Biology
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Vitamin D, synthesized in skin via UV radiation, is crucial for bone health and muscle function. Emerging research highlights its potential role in preventing diseases like diabetes and cancer.

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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Published on: May 4, 2018

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Oncology

Background:

  • Vitamin D is primarily synthesized in the skin upon exposure to ultraviolet radiation.
  • It plays a vital role in calcium absorption, essential for maintaining normal bone health.
  • Vitamin D is also recognized for its importance in muscle function and has been linked to protection against diseases such as diabetes.

Purpose of the Study:

  • To explore the multifaceted roles of vitamin D beyond bone health.
  • To investigate the potential of vitamin D compounds and their analogs in therapeutic applications.
  • To examine the emerging evidence for vitamin D's role in cancer prevention.

Main Methods:

  • Review of existing literature on vitamin D synthesis, metabolism, and function.
  • Analysis of epidemiological studies investigating the association between vitamin D levels and disease risk.
  • Exploration of research on vitamin D analogs and their specific pathways of action.

Main Results:

  • Established role of vitamin D in calcium absorption and bone maintenance.
  • Growing evidence implicating vitamin D in muscle function and protection against diabetes.
  • Emerging epidemiological data suggests a novel protective role of vitamin D against cancer.

Conclusions:

  • Vitamin D is essential for skeletal and muscular health.
  • Vitamin D compounds exhibit diverse therapeutic potentials through specific action pathways.
  • Further research into vitamin D's role in cancer prevention is warranted, supported by epidemiological findings.