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Published on: July 27, 2014
Plasmin therapy enhances mobilization of HPCs after G-CSF
Marc Tjwa1, Stefan Janssens, Peter Carmeliet
1Vesalius Research Center, Leuven, Belgium.
Abstract:
The role of proteinases in the mobilization of hematopoietic progenitor cells (HPCs) after granulocyte colony-stimulating factor (G-CSF) remains unclear. Here we report that genetic loss of the plasminogen activator inhibitor Pai-1 or of the plasmin inhibitor alpha2-antiplasmin increases HPC mobilization in response to G-CSF. Moreover, thrombolytic agents, such as tenecteplase and microplasmin, enhance HPC mobilization in mice and humans. Taken together, these findings identify a novel role for plasmin in augmenting HPC mobilization in response to G-CSF.
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