Phase gradient mapping as an aid in the analysis of object-induced and system-related phase perturbations in MRI

In this note we wish to demonstrate the utility of phase gradient mapping (PGM) as an aid in the analysis and characterization of object-induced and system-related macroscopic phase perturbations in MRI. To achieve this goal, phase gradient maps and, if applicable, field gradient maps were derived from standard phase images via a forward difference operator taking into account phase wraps. By way of phantom experiments, PGM was shown to provide reliable phase and field gradient information, even in regions with multiple phase wraps. Phase gradient mapping was further shown to allow positive identification of local phase and field perturbations and global discrimination between positive and negative local susceptibility deviations. The suitability of PGM for in vivo studies was demonstrated by a 3D brain examination of a healthy volunteer.