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Reflex changes in intestinal tone: relationship to perception.

J M Rouillon¹, F Azpiroz, J R Malagelada

¹Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Spain.

The American Journal of Physiology

|August 1, 1991

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Intestinal distension can modulate intestinal tone via reflexes. Unperceived distensions triggered relaxation, while perceived ones did not, suggesting distinct mechanisms for pain and reflex responses.

Area of Science:

Gastroenterology
Neurogastroenterology
Visceral Physiology

Background:

Intestinal tone, the tonic muscular activity of the intestine, plays a role in gut motility.
Intestino-intestinal reflexes are neural pathways that can influence gut function.

Purpose of the Study:

To investigate the modulation of intestinal tone by intestino-intestinal reflexes.
To explore the relationship between intestinal distension, perception, and reflex responses in healthy volunteers.

Main Methods:

Utilized an electronic barostat to measure intestinal tone variations in the proximal jejunum of healthy volunteers.
Administered graded balloon distensions at varying distances from the barostat bag to assess reflex responses and perception.
Validated the barostat technique with glucagon-induced intestinal relaxation.

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Main Results:

Intestinal distension induced both perception and reflex relaxation of intestinal tone.
Unperceived distensions elicited significant reflex relaxation, whereas higher-level, perceived distensions did not.
A dissociation was observed between the perception of distension and the reflex modulation of intestinal tone.

Conclusions:

Intestinal distension can modulate intestinal tone through intestino-intestinal reflexes.
The mechanisms mediating visceral perception and reflex intestinal tone changes appear to be distinct.
These findings contribute to understanding the complex neural regulation of gastrointestinal function.